克罗米酚对男性很低促性腺素性功能减退症有效

洛杉矶（汤森社健康海外版）1月初四日报道：据发表在12月初出海外版的《怀孕与不育》华尔街日报的一项报告指出克罗米酮对以外较低促性腺素性功能有所改善的未成年病变有利。来自伯明翰南卡罗来纳大学的该报告的第一作者Scott J. Whitten博士在做汤森通讯社采访谈起：“病症或于对HH病变在做危害性更大和更为价格昂贵的治疗（例如注射促性腺激素类）前展开4个月初的克罗米酮在在治疗是有利的。”Whitten博士和熟人分析了克罗米酮对10名HH未成年病变（HH是导致未成年不育的罕有因素）是否是有效。报告称作克罗米酮治疗1年后，4名卡尔曼(氏)syndrome病变中都只有一名病变的胎盘溶解度上升而全小脑功能有所改善症病变的胎盘缺乏病因均不能获得改善。相反，该报告指出3名成年发病的病症HH未成年病变经过3个月初克罗米酮的治疗胎盘溶解度有了明显上升。迄今该组病变已是两名回复了怀孕能力。Whitten博士却说：“除非对克罗米酮治疗不能化学反应，我们一定会因为副作用停止对病变适用该抗生素。”最后作者总结却说：“因为必要条件有限，对HH病变促性腺激素类抗生素和克罗米酮的随机分析较难展开，然而利用多三部的严格必需规范对病变展开分级显然设法进一步验证克罗米酮回复未成年较低怀孕能力的持续性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

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总编辑： 张靖